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In March 2005, researchers in Madrid reported that high doses of apple polyphenols “increased glutathione concentration and gene expression of Cu/Zn superoxide dismutase and catalase…” Increased gene expression of catalase. Exactly what the UW researchers engineered their long-lived mice to do. But in the Madrid study, they did it with polyphenols found in apples. And they didn’t just increase catalase. They increased concentration and gene expression of catalase, and all the other major antioxidant enzymes.
In 2004, Chinese researchers reported that a single apple polyphenol “significantly increased… the activity of SOD.” (In anti-aging circles, SOD [superoxide dismutase] is considered even more important than catalase.)
The SODzyme® formula also contains GliSODin®, a patented, plant-derived form of SOD. In an animal study, small amounts of orally administered GliSODin® raised blood levels of SOD by 89% and increased catalase levels by 171%!